The three-member delegation, headed by the president of parliament's influential foreign policy committee, Allaeddine Boroujerdi, is expected to meet Syrian President Bashar al-Assad in Damascus, one official said.
Their visit comes after US President Barack Obama said on Friday the United States was weighing "limited, narrow" action against Syria, insisting the world had a duty to act after it concluded Assad's regime had gassed to death hundreds of women and children.
Syria's government has denied using chemical weapons and has pointed the finger of blame at "terrorists" -- its term for rebels seeking to topple Assad.
"The purpose of this visit is to examine the situation in Syria, condemn the use of chemical weapons by terrorist groups, and insist on the need to find a political solution to the Syria crisis," parliamentary official Hossein Cheikholislam was quoted as saying on the Iranian parliament's website.
Iran, Damascus's main regional ally, has issued stern warnings against any US-led military action targeting Syria, with supreme leader Ayatollah Ali Khamenei saying it would be a "disaster" for the region.
